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Sarah
E. London
Graduate student, Neuroscience IDP Program, Laboratory of Neuroendocrinology,
UCLA
Principle Research Interests:
In the zebra finch, estrogen is a masculinizing steroid for the sexually
dimorphic song system. Contrary to traditional theories, the gonads
are probably not the source of these estrogens. I am interested in testing
the idea that the zebra finch brain is itself capable of synthesizing
masculinizing steroids, and that the male brain has a greater capacity
than the female brain. Therefore, I am mapping the expression levels
and patterns of three steroidogenic enzymes: side chain cleavage (CYP11A1),
3b-hydroxysteroid dehydrogenase (3b-HSD), and 17a hydroxylase/17,20
lyase (CYP17) in developing and adult brains. Neurosteroidogenesis. Sex differences. Neural development. Action of sex steroids in brain.
E-mail: slondon@ucla.edu
Education:
B.A. Middlebury College, Middlebury, VT
Selected Publications:
Saldanha, CJ, Schultz, JD, London, SE, Schlinger, BA. (2000). Telencephalic
aromatase but not a song circuit in a sub-oscine passerine, the golden-collared
manakin (Manacus vitellinus). Brain Behavior and Evolution.
2000. 56(1) 29-37
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=BBE&action=render&rendertype=abstract&uid=BBE.bbe56029
Schlinger BA, Soma KK, London S.E. (2001). Neurosteroids and brain sexual
differentiation. Trends Neuroscience. 24(8):429-31.
http://reviews.bmn.com/browse/areas/record?uid=TINS.etd00816_01662236_v0024i08_00001855
Selected Abstracts:
Saldanha, CJ, London, SE, Sanford, K, Clayton, NS & Schlinger, BA.
(1998). Androgen metabolism in the juvenile oscine forebrain: a cross-species
comparison at neural loci implicated in learning and memory. Society
for Neuroscience Abstracts. 24(1):699.
Schlinger, BA, London, SE, Schultz, JD, Saldanha, CJ. (1998). Aromatase
in the brain of a sub-oscine bird. Society for Neuroscience Abstracts.
24(1):698.
London SE, Schlinger BA. (2002). CYP17 Expression in Adult and Developing
Zebra Finch Brain. Society for Behavioral Neuroendocrinology Abstracts.
Hormones and Behavior. 40(4):478.
London SE, Schlinger BA. (submitted 2002). CYP17 Expression in Zebra
Finch Brain. Society for Neuroscience Abstracts.
Affiliations:
Society for Neuroscience
Society for Behavioral Neuroendocrinology
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